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Schematic of the metal-dependent dynamic equilibrium of M17 aminopeptidase oligomeric species . As metal ion concentration increases, the M17 aminopeptidase dynamic equilibrium shifts toward generation of active hexameric species. In low metal ion concentration, monomers self-associate to form dimers. As metal ion concentration increases, monomers associate with the existing oligomers to form tetramers and then hexamers.
