Table 1.
Cox proportional hazards model analysis of overall survival in LUSC patients.
| Overall survival (n = 144) | ||||||
|---|---|---|---|---|---|---|
| Variables | Univariate analysis | Multivariate analysis | ||||
| HR | 95% CI for HR | P -value | HR | 95% CI for HR | P -value | |
| Age (≥60/<60) | 1.1 | (0.57–2.1) | 0.81 | |||
| Sex (male/female) | 1.4 | (0.80–2.5) | 0.23 | |||
| Smoking (smoker/non-smoker) | 0.3 | (0.082–1.4)) | 0.20 | |||
| pStage (II, III or IV/I) | 1.0 | (1.0-1.0) | 0.58 | |||
| pN (I, II, III or X/0) | 1.0 | (0.61–1.7) | 0.92 | |||
| pM (I or X/0) | 1.2 | (0.37–3.8) | 0.79 | |||
| pT (II, III or IV/I) | 1.2 | (0.71–2.2) | 0.50 | |||
| Location (peripheral/central) | 1.3 | (0.52–3.2) | 0.57 | |||
|
Longest dimension
(≥median/<median) |
1.0 | (0.60–1.6) | 0.92 | |||
|
Intermediate dimension
(≥median/<median) |
0.77 | (0.47–1.2) | 0.29 | |||
|
Shortest dimension
(≥median/<median) |
0.77 | (0.45–1.3) | 0.35 | |||
| New tumor event after initial treatment (YES/NO) | 1.8 | (1.0–3.0) | 0.034* | 2.1 | (1.2–3.6) | 0.01** |
| Mutation load (high/low) | 0.77 | (0.48–1.2) | 0.28 | |||
| Group (TSG mutated group/TSG non-mutated group) | 0.64 | (0.37–1.1) | 0.11 | |||
| KLK5 (high/low) | 1.0 | (0.63–1.7) | 0.92 | |||
| PGC (high/low) | 1.2 | (0.72–1.9) | 0.55 | |||
| C7(high/low) | 1.2 | (0.75–2) | 0.43 | |||
| HGF(high/low) | 1.0 | (0.65–1.7) | 0.84 | |||
| PLA2G2A (high/low) | 1.6 | (1.0–2.7) | 0.046* | 1.8 | (1.0–3.2) | 0.04* |
| IL1RL1 (high/low) | 0.75 | (0.46–1.2) | 0.23 | |||
| CCR2(high/low) | 0.77 | (0.48–1.2) | 0.29 | |||
| ALOX15B (high/low) | 1.2 | (0.73–1.9) | 0.50 | |||
| CXCL11 (high/low) | 0.84 | (0.52–.14) | 0.49 | |||
| FCN3(high/low) | 1.8 | (1.1–2.9) | 0.024* | 1.5 | (1.9–2.7) | 0.12 |
HR, hazard ratio; CI, confidence interval.
*p < 0.05; **p < 0.01.