Table 5.
Associations between LEPR SNPs and family history of keloids.
| SNP | Family-history kleoid n |
No-family-history keloid n |
Normal controls n |
P-valuea | P-valueb | OR (95%) CIb | P-valuec | OR (95%) CIc |
|---|---|---|---|---|---|---|---|---|
| rs1137101 | ||||||||
| Codominant alleles AA/GG | 3/46 | 8/227 | 2/231 | 0.051 | 0.029 | 7.533 (1.224–46.349) | 0.078 | 4.070 (0.855–19.376) |
| Dominant AA+GA/GG | 12/46 | 67/227 | 68/231 | 0.937 | 0.732 | 0.886 (0.444–1.768) | 0.989 | 1.003 (0.683–1.472) |
| Recessive AA/GA+GG | 3/55 | 8/286 | 2/297 | 0.039 | 0.008 | 8.100 (1.323–49.603) | 0.052 | 4.154 (0.875–19.727) |
| Allele G/A | 101/15 | 513/75 | 528/70 | 0.839 | 0.709 | 0.893 (0.491–1.622) | 0.581 | 0.907 (0.641–1.284) |
| rs1938496 | ||||||||
| Codominant alleles CC/TT | 5/38 | 19/179 | 10/191 | 0.133 | 0.110 | 2.513 (0.813–7.769) | 0.080 | 2.027 (0.918–4.478) |
| Dominant CT+CC/TT | 20/38 | 115/179 | 108/191 | 0.674 | 0.812 | 0.931 (0.516–1.680) | 0.452 | 1.136 (0.815–1.584) |
| Recessive CC/CT+TT | 5/53 | 19/275 | 10/289 | 0.111 | 0.067 | 2.726 (0.896–8.296) | 0.078 | 1.997 (0.912–4.370) |
| Allele C/T | 25/91 | 134/454 | 118/480 | 0.436 | 0.654 | 1.118 (0.687–1.817) | 0.198 | 1.201 (0.909–1.587) |
| rs6588147 | ||||||||
| Codominant alleles AA/GG | 2/40 | 8/219 | 7/231 | 0.818 | 0.541 | 1.650 (0.331–8.229) | 0.722 | 1.205 (0.430–3.380) |
| Dominant GA+AA/GG | 18/40 | 75/219 | 68/231 | 0.374 | 0.177 | 1.529 (0.824–2.838) | 0.431 | 1.163 (0.798–1.696) |
| Recessive AA/GA+GG | 2/56 | 8/286 | 7/292 | 0.878 | 0.623 | 1.490 (0.302–7.359) | 0.768 | 1.167 (0.418–3.260) |
| Allele G/A | 96/20 | 505/83 | 523/75 | 0.368 | 0.173 | 0.688 (0.401–1.180) | 0.425 | 0.873 (0.624–1.220) |
| rs7555955 | ||||||||
| Codominant alleles GG/AA | 3/35 | 13/193 | 10/220 | 0.530 | 0.353 | 1.886 (0.494–7.192) | 0.363 | 1.482 (0.635–3.456) |
| Dominant GA+GG/AA | 23/35 | 101/193 | 79/220 | 0.039 | 0.041 | 1.830 (1.019–3.287) | 0.036 | 1.457 (1.025–2.073) |
| Recessive GG/GA+AA | 3/55 | 13/281 | 10/289 | 0.712 | 0.496 | 1.576 (0.420–5.913) | 0.497 | 1.337 (0.577–3.099) |
| Allele G/A | 26/90 | 114/474 | 89/509 | 0.045 | 0.043 | 1.652 (1.011–2.700) | 0.039 | 1.375 (1.015–1.864) |
LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval.
a
Family-history keloid vs no-family-history keloid vs normal controls;
b
Family-history keloid vs normal controls;
c
No-family-history keloid vs normal controls.
Bold fonts indicate the P values of codominant alleles in different groups.