Table 5.

Pharmacokinetic parameters of moxifloxacin (MX) in wound exudate after a 1‐hour infusion of 400 mg MX

Pat.	C max (mg/L)	Q E/P of C max	T max (h)	T last (h)	C last (mg/L)	AUC t (mg*h/L)	AUC t Plasma (mg*h/L)	Q E/P of AUC
2	4.55	1.69	1.0	12.0	1.28	34.36	26.1	1.32
3	0.41	0.17	12.0	12.0	0.41	3.54	17.2	0.21
5	1.23	0.31	12.0	24.0	0.54	17.99	48.6	0.37
6	4.51	0.87	1.0	12.0	1.31	34.25	40.1	0.85
7	0.82	0.38	1.0	24.0	0.11	12.06	17.2	0.70
8	0.19	0.05	12.0	12.0	0.19	1.14	28.4	0.04
10	3.18	1.18	2.2	24.0	0.48	35.67	33.4	1.07
11	1.51	0.44	12.0	24.0	0.15	23.31	46.1	0.51
12	1.89	0.83	1.0	24.0	0.09	14.55	20.1	0.72
13	0.77	0.26	13.8	24.0	0.43	12.04	32.8	0.37
14	0.94	0.29	12.0	24.0	0.40	13.67	39.7	0.34
15	1.87	0.80	2.9	24.0	0.14	18.47	19.7	0.94
16	3.34	1.76	2.2	30.2	0.13	36.08	33.0	1.09
17	0.71	0.22	12.0	24.0	0.14	9.11	31.1	0.29
18	1.92	0.99	3.0	24.0	0.18	17.30	24.2	0.71
19	4.38	0.97	1.8	25.5	0.33	34.47	44.5	0.77
20	1.91	0.65	1.3	25.0	0.49	25.30	35.0	0.72
21	0.39	0.10	12.0	24.0	0.15	5.54	38.3	0.14
n	18	18	18	18	18	18	18	18
Mean	1.92	0.67	6.4	21.8	0.39	19.4	32.0	0.62
SD	1.47	0.52	5.4	5.6	0.36	11.7	9.9	0.36
RSD	76	77	84	26	95	60	31	58
Median	1.69	0.54	3.0	24.0	0.26	17.6	32.9	0.71
Q25	0.78	0.27	1.4	24.0	0.14	12.0	24.7	0.35
Q75	2.86	0.95	12.0	24.0	0.47	32.0	39.3	0.83
Min	0.19	0.05	1.0	12.0	0.09	1.1	17.2	0.04
Max	4.55	1.76	13.8	30.2	1.31	36.1	48.6	1.32

Abbreviations: AUC _t, area under curve for exudate concentration; AUC _t‐plasma, area under curve for corresponding plasma concentration; C _last, concentration at last time point; C _max, peak concentration; Q _E/P, quotient between exudate and plasma; T _last, time point of last probe; T _max; time point of probe with peak concentration.

The calculations were performed by means of a non‐compartmental model because of wide value dispersion.