Figure 3.

Overall structures of the catalytic domain of poly(ADP-ribosyl) polymerase 1 (PARP1) and the ART domain of tankyrase1 (TNKS1) and similarities in the ligand-binding sites.A, PARP1 catalytic domain is composed of the helical domain and ART domain. B, TNKS1 ART domain. The broken line shows the disordered region of TNKS1 D-loop that is not modeled due to the absence of electron density. Recognition of talazoparib by (C) PARP1 and (D) TNKS1 is similar in the two proteins. ART, ADP-ribosyltransferase; D-loop, donor loop.