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. 2020 Nov 22;296:100042. doi: 10.1074/jbc.RA120.015306

Figure 1.

Figure 1

Overall structure of human B3GNT2 luminal domain.A, synthesis of polylactosamine on tetraantennary N-glycan catalyzed by B3GNT and B4GALT enzymes. B, B3GNT2 is a type II transmembrane protein with a short N-terminal cytosolic segment, a transmembrane region, and a C-terminal domain in Golgi lumen. C, secondary structure topology of human B3GNT2 luminal domain. N-terminal domain is colored in blue, and GT-A domain is colored in magenta. Figure was prepared with TopDraw (48). D, overall structure of B3GNT2_UDP (chain A). N-terminal domain is colored in blue, and GT-A domain is colored in pink. The three common sequence motifs in B3GT family are colored in green. Magnesium ion is shown as a gray sphere, and UDP is shown as cyan sticks. Disulfide bonds are highlighted in yellow. E, superposition of human B3GNT2 luminal domain (blue and pink) and the catalytic domain (GT-A domain) of mouse Manic Fringe (wheat).