Figure 1.

Development of the computational modelling framework used to conduct the studies simulating release of sodium pyruvate (NaPy) from a novel prophylactic dressing: A, optical coherence tomography (OCT) image of the sacral skin of a 67‐years‐old female used for the OCT‐based modelling. B, The four anatomical model variants, representing four levels of skin roughness (R1‐R4). C, Zoom‐in on the stratum corneum (SC) and epidermis layers of the skin. The roughness criterion was set as the vertical distance between the top of the highest fold to the bottom of the lowest valley. D, The thin‐slice transient finite element computational model of NaPy diffusing from the dressing (set as an infinite reservoir here) into the skin