TABLE 5.
Percentage of absolute risk reduction of overall breast cancer according to quartiles of circulating carotenoids and polygenic risk score.
| Polygenic risk score | Additive P-interaction | ||||
|---|---|---|---|---|---|
| Carotenoids | Q1, ←0.8 | Q2, −0.8 to ←0.4 | Q3, −0.4 to <0.03 | Q4, ≥0.03 | |
| Q1, <84.6 μg/dL | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) | |
| Q2, 84.6 to <109.5 μg/dL | 4.2% (−16.9 to 24.9%) | 16.4% (−0.6 to 32.4%) | 9.7% (−6.0 to 26.6%) | 30.3% (18.1–42.8%) | |
| Q3, 109.5 to 142.1 μg/dL | 17.1% (−1.3 to 35.3%) | 2.5% (−16.4 to 21.3%) | 9.6% (−7.2 to 26.2%) | 24.8% (11.6–38.7%) | |
| Q4, ≥142.1 μg/dL | 14.9% (−4.4 to 34.4%) | 13.7% (−3.4 to 31.5%) | 17.1% (2.1–32.8%) | 28.6% (14.8–42.1%) | 0.05 |
Data are from the NHS and NHSII. N cases = 1919; N controls = 1695. ARR was calculated based on Surveillance, Epidemiology, and End Results age-specific incidence rates for White women with invasive breast cancers (2004–2008), the proportion of women in each age strata in the controls, and relative risk estimations, as well as the proportion of controls in each risk strata. Confidence intervals for ARR were computed using the delta method. Abbreviations: ARR, absolute risk reduction; NHS, Nurses' Health Study; NHSII, second cohort of the Nurses' Health Study.