Table 8.
Studies that used microbial indicators only to diagnose infection in chronic leg ulcers
| Author(s), year | Study design | Number of CLUs | Microbial indicators used |
|---|---|---|---|
|
Daróczy, 200619 Hungary |
Prospective randomised controlled trial To assess the effectiveness of (a) topical povidone‐iodine with and (b) without compression bandages, (c) to compare the efficacy of systemic antibiotics and topical antimicrobial agents to prevent the progression of superficial skin ulcers. |
63 patients with infected VLUs | Wound swab: the number of bacteria colonies is so high (105 Colonies/cm3) |
|
Dubhashi & Sindwani, 201590 India |
A prospective comparative study To evaluate the use of honey and phenytoin with respect to the process of wound healing, eradication of infection, pain relief and hospital stay |
150 patients: 32 wound infections, 22 VLUs | Culture positive swabs: MRSA was the most common organism isolated in the study (16%) along with other organisms like Pseudomonas and Klebsiella |
|
Imbernon‐Moya et al, 201791 Spain |
3 cases of a chronic venous ulcer infected by multi‐resistant bacteria including Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus | 3 infected VLUs | Culture positive infected by multi‐resistant bacteria including P. aeruginosa and methicillin‐resistant Staphylococcus aureus |
|
Lei et al, 201520 China |
A randomised controlled experiment | 26 patients with CLUs infected with P. aeruginosa | Bacterial culture confirmed P. aeruginosa |
|
Madhusudhan, 201621 India |
A prospective randomised controlled clinical trial over a period of 6 mo | 32 patients with chronic wounds infected with P. aeruginosa | Culture proven to be infected with P. aeruginosa |
|
Peral et al, 201075 Argentina |
A prospective uncontrolled study To investigate the effectiveness of bacterio‐therapy with Lactobacillus plantarum on infected chronic venous ulcers and on interleukin‐8 production |
34 patients with VLUs | A bacterial load at a level > 105 microorganisms per gram of tissue |
CLUs, chronic leg ulcers; MRSA, methicillin‐resistant Staphylococcus aureus; VLUs, venous leg ulcers.