Figure 3.

The predominant Fc γ receptor glycoforms identified in the tissue or serum from healthy donors. The N-glycans are scaled roughly to the appropriate size. The NK cell N-glycans increase the mass of the extracellular domain by 40%. The CD16 N45 glycan contributes to protein stability, the CD16a N162 glycan composition impacts antibody-binding affinity, and the CD32a N64 glycan inhibits antibody binding through cis-interactions on the neutrophil surface. N-glycan, glycans attached to Asn residues; NK, natural killer.