Table 1.
Properties of human Fc γ receptors
| FcγR | Function | Affinity | Major alleles | N-glycan sites | Expressed by |
|---|---|---|---|---|---|
| CD16a/FcγRIIIa | Activation | IgG3>IgG1>>IgG4>IgG2 | V158/F158 | 5 | NK, Mona, MΦa, Ta, Baa, Ma |
| CD16b/FcγRIIIb | Activation | IgG3>IgG1 | NA1/NA2/SH | 4/6/6 | N, Baa, Eb |
| CD32a/FcγRIIa | Activation | IgG1>IgG3>IgG2=IgG4 | H131/R131 | 2 | MΦ, N, P, M, E |
| CD32b/FcγRIIb | Inhibition | IgG1=IgG3=IgG4>IgG2 | na | 3 | B, MΦ, D, Ba, Mona, Na |
| CD32c/FcγRIIc | Activation | IgG1=IgG3=IgG4>IgG2 | na | 3 | Ba, NKa |
| CD64/FcγRI | Activation | IgG1=IgG3>IgG4 | na | 7 | MΦ, Mon, D, M, Nb |
B, B cells; Ba, basophils; D, dendritic cells; E, eosinophils; M, mast cells; MΦ, macrophages; Mon, monocytes; N, neutrophils; na, not applicable; NK, natural killer cells; P, platelets; T, T cells.
a
Indicates expression in a subset of cells.
b
Indicates inducible expression.