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. 2021 Feb 25;12:633625. doi: 10.3389/fendo.2021.633625

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Copyright © 2021 Lafferty, Tanday, Moffett, Reimann, Gribble, Flatt and Irwin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of twice-daily administration of sea lamprey PYY [SL-PYY (1-36)] on (A, B) body weight, (C, D) % body weight change as well as cumulative (E, F) food and (G, H) fluid intake in streptozotocin (STZ)-diabetic Glu^CreERT2;Rosa26-eYFP and Ins1^Cre/+;Rosa26-eYFP mice. Parameters were measured prior to, and 11 days during, twice daily treatment with saline vehicle or SL-PYY(1-36) (25 nmol/kg bw) in STZ-diabetic Glu^CreERT2;Rosa26-eYFP and Ins1^Cre/+;Rosa26-eYFP mice. Values are mean ± SEM (n=6). ^Δp < 0.05, ^ΔΔp < 0.01, ^ΔΔΔp < 0.001 compared to appropriate non-diabetic control. *p < 0.05, **p < 0.01, ***p < 0.001 compared to appropriate STZ-diabetic control.