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. 2020 Nov 24;296:100100. doi: 10.1074/jbc.RA120.014888

Figure 1.

Figure 1

HDL NPs increase expression of de novo cholesterol synthesis genes and reduce expression of GPX4.A. Select gene microarray results from Ramos cells treated with HDL NPs or human HDL (hHDL) for 48 h. B and C. Western blot analysis of GPX4 expression in Ramos (B) and SUDHL4 (C) cells treated with HDL NPs or hHDL for 48 h. β-Actin was used as a loading control. D and E. RT-qPCR analysis for GPX4 expression in Ramos (D) and SUDHL4 (E) cells treated with HDL NPs for 24 or 48 h. ∗p < 0.05 vs 0 nM. HDL NPs, high-density lipoprotein–like nanoparticles.