Figure 5.

HDL NPs induce ferroptosis in vivo.A. RT-qPCR analysis for GPX4 from SUDHL4 tumor xenografts isolated following HDL NP treatment. ∗p < 0.05 vs PBS control. B. Flow cytometric analysis of C11-BODIPY fluorescence in SUDHL4 tumor xenograft cells following HDL NP treatment. Flow histogram displaying C11-BODIPY fluorescence (left). Median fluorescent intensity (MFI) graph (right). ∗p < 0.05 vs PBS control. HDL NPs, high-density lipoprotein–like nanoparticles; PBS, phosphate buffered saline.