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CR and serine supplementation mediate longevity by independent mechanisms.A, Acetic acid content in the media of CR, NR, NR + L-serine (5, 10, 20 mM) cultures was measured over the first 72 h of the aging assays (mean ± SD, n = 3). B, CLS of BY4741 growing in the NR or CR media condition supplemented with 10 mM L-serine (n = 3). C, mean CLS statistics from panel B calculated using OASIS 2.
