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. 2020 Nov 23;296:100034. doi: 10.1074/jbc.RA120.014126

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Overexpression of ST6Gal-I in Suit2 cells promotes activation of metastasis-associated gene networks including stemness and epithelial to mesenchymal transition (EMT) pathways. A, graph depicts the top 20 IPA Biological Functions altered in Suit2 overexpression (OE) cells as compared with Suit2 empty vector (EV) cells. Fourteen of the Biological Functions altered in Suit2 OE cells were also altered in both S2-LM7AA and S2-013 cells (red bars). Another two Functions were shared with one of the two subclones (green bars). B, gene Set Enrichment Analysis of Suit2 OE versus EV cells show that OE cells are enriched in the following pathways: Wnt (normalized enrichment score [NES] = 1.34; false discovery rate [FDR] = 0.10), Hedgehog (NES = 1.84, FDR = 0.001), EMT (NES = 2.24, FDR < 0.0005) and Hypoxia (NES = 1.85, FDR = 0.001).