Table 2.
Transcriptome changes in INK128-treated NF2-null AC-CRISPR cells
| Symbol | Ensemble ID | log2FC | FC | p value | BH adj p value |
|---|---|---|---|---|---|
| IRS2 | ENSG00000185950 | 1.45 | 2.73 | 4.57 × 10−12 | 3.59 × 10−10 |
| IGF1R | ENSG00000140443 | 0.79 | 1.72 | 2.77 × 10−10 | 1.05 × 10−08 |
| INSR | ENSG00000171105 | 0.56 | 1.47 | 1.06 × 10−03 | 3.22 × 10−03 |
| IGF2R | ENSG00000197081 | 0.43 | 1.34 | 4.23 × 10−04 | 1.48 × 10−03 |
| ERBB3 | ENSG00000065361 | −0.74 | −1.67 | 5.29 × 10−05 | 2.55 × 10−04 |
| ERBB4 | ENSG00000178568 | −1.58 | −2.99 | 9.59 × 10−09 | 1.92 × 10−07 |
| MTOR | ENSG00000198793 | −0.34 | −1.27 | 2.31 × 10−04 | 8.91 × 10−04 |
| NRG1 | ENSG00000157168 | −0.48 | −1.39 | 6.10 × 10−02 | ns |
AC-CRISPR, CRISPR-modified arachnoidal cells; BH adj, Benjamini-Hochberg adjusted; FC, fold change; ns, not significant.