Table 3.
SynergyFinder scores from NF2-null meningioma lines co-treated with INK128 and BMS-754807
| Cell line | Modela | SynergyFinder |
|
|---|---|---|---|
| Average score | Most synergistic area score | ||
| Ben-Men-1 (immortalized MN) | HSA | 9.99 | 24.79 |
| Ben-Men-1 (immortalized MN) | Loewe | 8.98 | 21.78 |
| Ben-Men-1 (immortalized MN) | Bliss | 8.84 | 21.98 |
| Ben-Men-1 (immortalized MN) | ZIP | 8.85 | 21.30 |
| MN1-LF (immortalized MN) | HSA | 9.55 | 25.76 |
| MN1-LF (immortalized MN) | Loewe | 9.14 | 21.27 |
| MN1-LF (immortalized MN) | Bliss | 10.21 | 22.52 |
| MN1-LF (immortalized MN) | ZIP | 10.26 | 22.76 |
| MN646 C (primary MN) | HSA | 8.69 | 18.78 |
| MN646 C (primary MN) | Loewe | 7.84 | 17.38 |
| MN646 C (primary MN) | Bliss | 9.02 | 22.64 |
| MN646 C (primary MN) | ZIP | 9.04 | 21.71 |
| MN658 (primary MN) | HSA | 9.36 | 21.29 |
| MN658 (primary MN) | Loewe | 9.00 | 19.87 |
| MN658 (primary MN) | Bliss | 8.14 | 20.92 |
| MN658 (primary MN) | ZIP | 8.14 | 20.86 |
MN, meningioma.
a
Synergy reference models: HSA, highest single agent; Loewe, Loewe additivity; Bliss, Bliss independence; ZIP, zero interaction potency.