Figure 3.

Agonist-promoted desensitization of the TAS2R14 [Ca²⁺]_iresponse is attenuated by GRK2 knockdown.A, representative Western blot showing the extent of GRK2 knockdown in cells used for experiments in panel B. B, results (mean ± SE) from five experiments. ∗Slope from 10 to 50 s as determined by linear regression is different from control (scrambled) siRNA, p < 0.01 (see also Table 1). [Ca²⁺]_i, intracellular calcium; GRK, G protein–coupled receptor kinase; TAS2R14, bitter taste 2 receptor member 14.