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. 2021 Jan 23;296:100328. doi: 10.1016/j.jbc.2021.100328

Figure 9.

Figure 9

The molecular-level understanding of how type II PKS ACPs interact with KSCLFs can be used to inform strategic type II PKS redesign experiments to gain access to novel chemical diversity. Shown here is the ishigamide ACP docking to its cognate KSCLF (PBD: 6KXF) (65). The current understanding of type II PKS ACP–KSCLF binding is summarized in boxes with unanswered questions posed in thought bubbles. ACP, acyl carrier protein; KSCLF, ketosynthase chain length factor; PKS, polyketide synthase.