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. 2021 Feb 2;296:100364. doi: 10.1016/j.jbc.2021.100364

Figure 3.

Figure 3

The effect of KCC2 knockout on EGABAand intracellular Cl−levels.A, representative electrophysiological traces of DIV21 neurons infected with AAV-GFP or AAV-Cre at DIV3 showing the leak-subtracted muscimol-activated currents and the shift after 1 μM 11K application for control and B, knockout cells. The box plots show the quantification for the C, mean EGABA (nKCC2+/+ = 10, nKCC2−/− = 10 recordings), D, calculated Cl− concentration (nKCC2+/+ = 10, nKCC2−/− = 10 recordings) and E, 11K-induced shift (nKCC2+/+ = 6, nKCC2−/− = 8 recordings).