Table 4.
Chemical stability of CoQ10 in LBMEs and hydrophilic cream formulations
| Temperature | Time, days | CoQ10 content (SD) |
|||
|---|---|---|---|---|---|
| LBME1 | LBME2 | LBME3 | Cream | ||
| Refrigerator | 0 | 100.0 (9.9) | 100.0 (1.9) | 100.0 (11.4) | 100.0 (5.6) |
| 7 | 81.7 (17.3) | 107.5 (11.7) | 79.1 (7.1) | 118.0 (4.7) | |
| 14 | 114.9 (5.6) | 116.9 (3.3) | 104.8 (4.9) | 102.9 (5.6) | |
| Room temperature | 0 | 100.0 (9.9) | 100.0 (1.9) | 100.0 (11.4) | 100.0 (5.6) |
| 7 | 99.9 (2.2) | 80.3 (1.0) | 97.5 (11.0) | 123.5 (14.5) | |
| 14 | 99.9 (7.1) | 88.8 (2.8) | 72.0 (5.3) | 115.8 (22.7) | |
| 40°C | 0 | 100.0 (9.9) | 100.0 (1.9) | 100.0 (11.4) | 100.0 (5.6) |
| 7 | 95.7 (3.2) | 97.9 (5.4) | 87.3 (2.4) | 122.0 (12.8) | |
| 14 | 115.4 (8.9) | 106.8 (3.9) | 95.1 (5.6) | 110.2 (1.2) | |
LBME, lecithin-based ME; SD, standard deviation; COQ10, coenzyme Q10.