Meta‐regression on mortality in the PIs group and non‐PIs group. x = patients' enrolled year, average age, the incidence of PIs, and gender ratio, y = HR and circle diameters showed the weight of each study based on the random effect model. A, Meta‐regression analysis of the median of patients' enrolled year. B, Meta‐regression analysis of patients' average age. C, Meta‐regression analysis of the incidence of PIs of included studies. D, Meta‐regression analysis of male and female gender ratio of included studies. E, Sensitivity analysis with each study excluded