Table 3.

Integration of Salmonella into current immunotherapies.

Co-administer Salmonella with Current Immunotherapeutics	Engineered Salmonella Mediated Therapy	Carrying/Secreting RNAi or Antibodies of Immune Checkpoints
•Induces antitumor cytokines in TME	•Enhances tumor antigen(s) expression	•Inhibits PD-L1 of cancer cells
•Recruits more anti-tumor immune cells into the TME	•As a gene therapeutic delivery to affect cancer-related genes	•Activates CTL in the TME
•Attenuates immunosuppression in the TME		•Enhances targeting ability of immune checkpoint therapy and weakens irAEs