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. 2021 Feb 25;12:629059. doi: 10.3389/fimmu.2021.629059

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Copyright © 2021 Johansson, Yohannes, Koskela, Partanen and Saavalainen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Allotype expression of HLA class I and class II genes of 50 individuals. Allele-level UMIs of eight HLA genes (A–H) were normalized, grouped to allelic lineages, and plotted according to different lineages in Illumina cDNA data. Y-axis indicates the normalized unique UMIs (Log2) and X-axis indicates the names of the allelic lineages. Each dot refers to a UMI value and a solid bar indicates the median expression of the lineage. The number of samples are shown within parentheses. A Kruskal-Wallis test compared the ranks between the allelic lineages.