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. 2021 Mar 10;9(3):e001946. doi: 10.1136/jitc-2020-001946

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Biological effect and mechanism of oncostatin M (OSM) and interleukin (IL)-11 in intrahepatic cholangiocarcinoma (ICC) cells. (A) Western blot analysis showed the phosphorylation state of STAT3 and downstream STAT3 targets including vascular endothelial growth factor (VEGF), cyclin D1 and BCL-2 in ICC cells after OSM and IL-11 treatment. (B) CCK8 cell proliferation assay showed ICC cell proliferation in the indicated treatment groups. Data are shown as the mean±SD (n=6 for each group). (C) Matrigel-invasion assay showed the invasion of ICC cells in the indicated treatment groups. Data are shown as the mean±SD (n=6 for each group). (D) Colony-formation activity of ICC cells in the different treatment groups. Data are shown as the mean±SD (n=6 for each group). *P<0.05, **p<0.01, ***p<0.001.