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. 2021 Mar 10;9(3):e001946. doi: 10.1136/jitc-2020-001946

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Tumor-associated neutrophil (TAN) levels were correlated with tumor-associated macrophage (TAM) infiltration, p-STAT3 expression and prognosis in patients with intrahepatic cholangiocarcinoma (ICC). (A and B) Expression of CD66b, CD68 and p-STAT3 in representative ICC tumor samples, Scale bars: 100 μm. (C) A scatter plot illustrated the correlation between the numbers of TANs and TAMs and p-STAT3 expression. (D) The numbers of TANs and TAMs, p-STAT3 expression and the combination of those factors (TANs/TAMs) was predictive of prognosis in patients with ICC.