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. 2021 Mar 10;9(3):e001610. doi: 10.1136/jitc-2020-001610

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Comparison of tumor-infiltrating immune cell fractions in LARC tissues before and after CRT. (A) PCA of TIIC fractions from each sample before and after CRT. The first two principal components explaining most of the data variation are shown. (B) Differences in TIICs between paired LARC tissues before and after CRT. (C) Volcano plot visualizing the differential TIICs. The green and purple points in the plot represent subpopulations with significant differences (p<0.05). CRT, chemoradiation therapy; LARC, locally advanced rectal cancer; PCA, principal component analysis; RNAseq, RNA sequencing; TIICs, tumor-infiltrating immune cells.