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. 2021 Mar 10;9(3):e001610. doi: 10.1136/jitc-2020-001610

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Comparison of immune biomarker scores in LARC before and after CRT. Immune scores of the interferon (IFN)-γ signature. (A) The cytolytic activity (D) and the immune signature (G) from the RNAsequencing cohort. Immune scores of the IFN-γ signature (B), the cytolytic activity (E), and the immune signature (H) from the GSE15781 dataset. immune scores of the IFN-γ signature (C), the cytolytic activity (F), and the immune signature (I) from the GSE94104 dataset. CRT, chemoradiation therapy; LARC, locally advanced rectal cancer; RNAseq, RNA sequencing.