Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 4;47(5):75. doi: 10.3892/ijmm.2021.4908

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Anti-apoptotic and pro-autophagic effects of curcumin. Curcumin can upregulate the level of Nrf2 to induce the expression of HO-1, and it also plays an anti-apoptotic role by downregulating the levels of BAX, p62, and AMPK-mTOR, and phosphorylating Bcl-2 through AMPK and JNK1 pathways. In addition, curcumin can increase the ratio of LC3II/I and the level of Beclin-1. This way, curcumin can enhance autophagy and protect cells from further damage. Nrf2, nuclear factor E2-related factor 2; HO-1, heme oxygenase-1; AMPK, AMP-activated protein kinase; mTOR, mammalian target of rapamycin; JNK1, c-Jun N-terminal kinase; LC3, light chain 3; UVRAG, ultraviolet radiation resistance-associated gene protein; ATG5, autophagy-related protein 5.