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. 2021 Jan 6;20:100019. doi: 10.1074/mcp.RA120.002414

Fig. 5.

Fig. 5

HDX-MS reveals long-range allostery upon neddylation of CUL5. Comparison of the HDX-MS deuterium uptake into CKB-ASB9-ELOB/C-CUL5-RBX2 complex (brown symbols in plots) with the CKB-ASB9-ELOB/C-CUL5(NEDD8)-RBX2 complex (black symbols in plots) revealed that neddylation of CUL5 causes increased exchange in CUL5 residues (red) and decreased exchange in RBX2 residues (blue).