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HDX-MS reveals transient protection of CUL5 by the N terminus of ARIH2. Comparison of the HDX-MS deuterium uptake into ELOB/C-CUL5(NEDD8)-RBX2 complex (magenta symbols in plots) with the ELOB/C-CUL5(NEDD8)-RBX2-ARIH2 complex (black symbols in plots) revealed that the CUL5 regions that form the basic cleft and the surrounding residues are transiently protected upon ARIH2 binding (blue regions in structure).
