Table 5.

Summary of the outcome measurements of case serious studies

	Mean time of reepithelisation (days)	Reduction in WSA	Proportion of compellation of wound healing (%)	Blood flow	Safety and adverse reaction
Variji et al., 2015 26	6–8 weeks	Progressive reduction of WSA in four patients after 6–8 weekly treatment, mean reduction (1·21 ± 0·82 cm2)	N/A	N/A	Not observed
Wolff et al., 2011 31	2 wks (1–288)	N/A	74% complete wound closure	N/A	Not observed
Schaden et al., 2007 37	44 days (39·4 days for <10 cm2, and 1 month duration – 164·6 days for wound > 10 cm2, and duration > 1 month)	N/A	75% complete wound closure 81·0% complete wound closure in wound ≤10 cm2 versus 61·8% complete wound closure in wound ≥10 cm2 (P < 0·005) 83·0% complete wound closure for wound ≤ 1 month versus 57·1% for wound ≥1 month old (P < 0·001) 81·0% complete wound closure for acute wound versus 56·3% in chronic wound (P < 0·001)	N/A	Not observed

N/A, not available; WSA, wound surface area.