Fig. 3.
Differences in protein kdegvalues between species are correlated with protein abundance.A, correlation between kdeg values of two example proteins (Ptk7 and Rps26) and maximum life spans across species. The turnover–life span slope (TLS) measurements refer to slopes of the log-log plots. B, distribution of protein TLS values. Steep and shallow TLS values are most enriched in proteins mapped to red and cyan GO terms, respectively. C, correlation between protein TLS values and abundances (measured in mouse cells). The line indicates the line of best fit. The rS and p-values indicate the Spearman rank correlation coefficient and significance, respectively. D, correlation between median kdeg values and maximum life spans across species for the 500 most (red) and least (cyan) abundant proteins in the data set. CCT, chaperonin-containing tailless complex; GO, gene ontology.