Fig. 4.

Protein-protein interaction network of the differentially expressed proteins between tumor tissues of low-risk and high-risk subtype groups. (A-C) Protein-protein interaction network constructed with the differentially expressed proteins in cluster 1 (65 protein inputs; 38 proteins in the network, A), cluster 2 (70 protein inputs; 35 proteins in the network; B) and cluster 3 (49 protein inputs; 13 proteins in the network; C). Enriched pathways or GO terms are marked by colors. Nodes represent proteins and lines represent different interaction categories: light blue, from curated databases; pink, experimentally determined; green, gene neighborhood; red, gene fusions; blue, gene co-occurrence; yellow, text mining; black, co-expression; purple, protein homology.