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. 2021 Feb 17;13(4):4911–4925. doi: 10.18632/aging.202673

Table 1. Significance (p-value) and slope of the variation in CBF as a function of age and sex for the linear regression analysis for each GM and WM brain region studied.

NESMA filtered Unfiltered
Gray matter (GM) White matter (WM) Gray matter (GM) White matter (WM)
Age Sex Age Sex Age Sex Age Sex
p-value Slope p-value Slope p-value Slope p-value Slope p-value Slope p-value Slope p-value Slope p-value Slope
Whole Brain < 0.01 -0.11 < 0.01 -4.95 < 0.01 0.08 < 0.05 -1.90 < 0.01 -0.11 < 0.01 -4.92 < 0.01 0.07 < 0.1 -1.41
Frontal Lobes < 0.01 -0.16 < 0.01 -3.85 < 0.05 0.04 < 0.05 -1.44 < 0.01 -0.15 < 0.01 -3.85 < 0.05 0.02 > 0.1 -1.04
Occipital Lobes < 0.05 -0.10 < 0.01 -8.32 < 0.01 0.06 < 0.01 -2.56 < 0.1 -0.10 < 0.01 -8.35 < 0.01 0.04 < 0.01 -1.96
Parietal Lobes < 0.1 -0.08 < 0.01 -5.20 < 0.01 0.06 < 0.05 -1.66 > 0.1 -0.08 < 0.01 -5.32 < 0.05 0.04 < 0.05 -1.20
Temporal lobes < 0.05 -0.07 < 0.01 -4.82 < 0.01 0.05 < 0.01 -1.84 < 0.05 -0.07 < 0.01 -4.82 < 0.05 0.03 < 0.01 -1.34
Cerebellum < 0.05 -0.09 < 0.01 -5.64 < 0.05 0.04 < 0.01 -2.12 < 0.1 -0.10 < 0.01 -5.38 < 0.05 0.02 < 0.01 -1.85

All p-values presented are obtained after FDR correction. Results are shown for both CBF maps derived with or without the NESMA filtering of the ASL images.