Table 1. Characteristics of the study participants with different level of D-dimer.
| Total | D0(n=57) | D1(n=38) | D2(n=31) | D3(n=32) | P | |
| Age | 62(56-70) | 62(53-70) | 61(51-69) | 66(63-73) | 66(61-69) | 0.046 |
| Gender, Male | 91/158 | 28/57 | 18/38 | 21/31 | 24/32 | 0.035 |
| Death | 77/158 | 8/57 | 17/38 | 22/31 | 30/32 | <0.001 |
| Anticoagulant therapy | 49/158 | 14/57 | 14/28 | 10/31 | 11/32 | 0.593 |
| WBC (×109/L) | 10.1(6.4-15.6) | 6.5(4.8-9.4) | 9.6(6.5-12.5) | 12.8(10.2-17.2)# | 16.2(10.5-19.8)# | <0.001 |
| Lymphocyte(×109/L) | 0.6(0.4-0.9) | 0.8(0.6-1.2) | 0.5(0.3-0.7)# | 0.5(0.4-0.7)# | 0.4(0.3-0.6)# | <0.001 |
| Neutrophil (×109/L) | 8.7(5.0-14.6) | 4.9(3.2-8.2) | 8.5(5.3-11.9)* | 11.3(9.2-15.8)# | 15.2(9.6-19.1)# | <0.001 |
| Monocyte (×109/L) | 0.4(0.2-0.5) | 0.4(0.3-0.5) | 0.3(0.2-0.4) | 0.4(0.3-0.7) | 0.4(0.2-0.5) | 0.050 |
| RBC (×1012/L) | 3.9(3.5-4.4) | 4.0(3.5-4.4) | 3.8(3.2-4.5) | 3.9(3.5-4.5) | 3.8(3.6-4.1) | 0.562 |
| HGB (g/L) | 116(106-132) | 118(108-133) | 111(91-134) | 117(108-134) | 117(108-127) | 0.460 |
| PLT (×109/L) | 186(144-241) | 202(151-241) | 236(150-314) | 199(179-231) | 123(83-174)# | <0.001 |
| PFDP (μg/mL) | 20.2(4.2-81.3) | 2.7(1.6-4.2) | 12.8(7.6-25.8)# | 59.0(43.3-81.3)# | 112.7(100.0-131.7)# | <0.001 |
| Fbg (g/L) | 4.8(3.1-6.1) | 4.4(3.6-6.0) | 5.1(3.9-5.9) | 5.0(2.3-6.3) | 4.0(1.9-5.1) | 0.082 |
| TT (s) | 17.0(16.1-18.6) | 17.0(16.2-18.6) | 17.1(15.9-18.2) | 16.5(16.2-19.3) | 17.6(16.8-20.6) | 0.334 |
| PT (s) | 12.9(11.8-14.7) | 11.9(10.9-13.2) | 12.4(11.6-13.1) | 12.5(11.7-13.7) | 14.8(13.9-16.4)# | <0.001 |
| PTA (%) | 79.2(58.7-98.5) | 90.8(71.1-108.6) | 84.6(72.8-104.2) | 81.4(71.7-99.0) | 58(50.9-69.3)# | <0.001 |
| APTT (s) | 27.4(23.7-32.2) | 28.1(24.4-31.8) | 28.0(23.4-34.2) | 24.4(20.0-27.0)* | 30.2(26.0-36.2) | 0.002 |
| AT3 (%) | 89.5(72.8-109.2) | 92.2(72.0-119.2) | 91.5(76.9-103.4) | 93.7(73.6-118.0) | 82.1(64.2-100.2) | 0.253 |
| CRP (>160 mg/L) | 47/154 | 6/56 | 8/37 | 13/31† | 20/30† | <0.001 |
| PCT (>0.5 ng/mL) | 38/151 | 5/54 | 7/37 | 11/30† | 15/30† | <0.001 |
| Serum ferritin (>2000 ng/mL) | 45/142 | 9/54 | 12/34 | 11/27 | 13/27† | 0.017 |
| Cholesterol (mmol/L) | 3.4(3.0-4.1) | 3.6(3.0-4.2) | 3.5(2.9-4.4) | 3.5(3.1-3.9) | 3.1(2.4-3.7) * | 0.022 |
| Triglyceride (mmol/L) | 1.5(1.1-2.0) | 1.2(0.9-1.6) | 1.8(1.4-2.3) ** | 1.4(1.2-1.8) | 1.7(1.3-2.3) ** | <0.001 |
| Apolipoprotein A-1 (g/L) | 0.9(0.8-1.0) | 1.0(0.8-1.1) | 0.9(0.8-1.0) | 0.8(0.7-1.0) | 0.8(0.6-0.9)# | 0.001 |
| Apolipoprotein B (g/L) | 0.8(0.7-1.0) | 0.8(0.7-0.9) | 0.9(0.7-1.0) | 0.9(0.8-1.0) | 0.8(0.7-0.9) | 0.195 |
| Lipoprotein a (mg/L) | 149.5(78.0-273.1) | 158.7(100.3-332.5) | 149.4(104.8-291.9) | 150.1(83.0-272.5) | 147.4(64.1-192.9) | 0.703 |
| HDL (mmol/L) | 0.9(0.7-1.1) | 1.0(0.8-1.1) | 0.9(0.7-1.1) | 0.8(0.7-1.0) | 0.6(0.4-0.8) # | <0.001 |
| LDL (mmol/L) | 1.7(1.5-2.3) | 2.0(1.6-2.4) | 1.7(1.5-2.4) | 2.0(1.7-2.3) | 1.5(1.1-2.1) * | 0.022 |
| hnTNI (pg/mL) | 17.0(6.9-75.5) | 8.6(3.4-12.7) | 22.9(7.0-50.1) * | 39.5(9.8-133.8) ** | 121.2(43.8-846.2) # | <0.001 |
| BNP (pg/mL) | 51(21-115) | 28(11-55) | 69(24-119) * | 64(33-111) * | 131(44-218) # | <0.001 |
| LDH (U/L) | 453(310-647) | 301(230-383) | 465(336-627) ** | 479(419-683) # | 714(605-951) # | <0.001 |
| HBDH (U/L) | 358(235-538) | 228(180-305) | 394(278-525) # | 422(313-605) # | 609(485-792) # | <0.001 |
| CK (U/L) | 105(60-202) | 98(62-170) | 94(48-178) | 119(57-253) | 140(75-291) | 0.297 |
| CK-MB (U/L) | 15(11-22) | 12(8-17) | 15(9-22) | 18(14-24) ** | 20(16-48) # | <0.001 |
| ALB (g/L) | 29.5(26.8-31.7) | 31.4(29.2-34.8) | 30.3(27.9-32.1) | 28.0(25.2-29.8) # | 27.0(25.0-28.0) # | <0.001 |
| ALT (U/L) | 38(22-61) | 30(15-50) | 36(20-56) | 42(27-62) | 47(31-69) | 0.045 |
| AST (U/L) | 43(31-60) | 34(28-49) | 43(30-60) | 47(33-60) | 59(38-72) # | 0.001 |
| Cholinesterase (U/L) | 6308(4773-7659) | 6968(5776-8572) | 6550(4936-7166) | 5511(4216-6309) ** | 4943(4130-6016) # | <0.001 |
| Cr (μmol/L) | 73.3(59.7-98.6) | 70.8(58.3-83.9) | 72.6(58.4-95.6) | 73.4(65.5-106.9) | 84.5(67.0-108.0) | 0.216 |
| eGFR (ml/(min*1.73m2)) | 99.1(70.3-117.6) | 104.3(83.6-113.3) | 104.8(66.3-130.0) | 98.3(62.9-119.2) | 87.5(62.2-109.1) | 0.401 |
| Uric acid (umol/L) | 212(145-299) | 235(188-319) | 176(136-276) | 216(138-303) | 241(124-288) | 0.199 |
| Cystatin-c (mg/L) | 1.1(0.9-1.4) | 1.0(0.8-1.1) | 1.3(1.0-1.5) ** | 1.1(0.9-1.3) | 1.2(1.0-1.6) ** | 0.001 |
| DIC (ISTH criteria) | 21/158 | 0/57 | 6/38† | 6/31† | 9/32† | <0.001 |
| PaO2/FiO2<100 | 74/158 | 23/57 | 23/38 | 14/31 | 14/32 | 0.264 |
| SOFA score | 4(3-5) | 3(2-4) | 4(3-5)* | 5(4-5)** | 6(4-7) # | <0.001 |
| NIV | 68/158 | 10/57 | 17/38 | 16/31 | 25/32 | <0.001 |
| IMV | 81/158 | 10/57 | 24/38 | 25/31 | 22/32 | <0.001 |
| NIV+IMV | 102/158 | 16/57 | 27/38 | 28/31 | 31/32 | <0.001 |
Compared with D0 group, *<0.05; **<0.01; #<0.001. † means P<0.05 after adjusting by Bonferroni way.