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. 2021 Feb 25;13(4):6182–6193. doi: 10.18632/aging.202626

Figure 6.

Figure 6

DEX alleviated MTX-induced iron overload and ROS overproduction in HT22 cells via NCOA4 mediated ferritinophagy. (A, C) Fluorescence microscope with Ca-AM probe analysis and quantitative results of iron fluorescence intensity in HT22 cells with different treatments. n=3; #p<0.05, vs Control; *p<0.05, vs MTX group; &p<0.05, vs MTX+DEX+NC-siRNA. (B, D) Fluorescence microscope with ROS probe analysis and quantitative results of ROS fluorescence intensity in HT22 cells with different treatments. n=3; #p<0.05, vs Control; *p<0.05, vs MTX group; &p<0.05, vs MTX+DEX+NC-siRNA. (E) Quantitative results of total iron content in HT22 cells with different treatments. n=3; #p<0.05, vs Control; *p<0.05, vs MTX group; &p<0.05, vs MTX+DEX+NC-siRNA.