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. 2021 Feb 1;13(4):5250–5262. doi: 10.18632/aging.202445

Table 1. Basic characteristics of aneurysm rupture and NLR in patients with intracranial aneurysm.

Characteristics rIAs uIAs p
NLR<4 (n=76) NLR≥4 (n=72) NLR<4 (n=363) NLR≥4 (n=21)
Age, y; mean (SD) 51.78 (10.22) 55.11 (12.57) 54.23 (10.02) 53.76 (10.56) 0.218
Women (%) 43 (56.6) 37 (51.4) 234 (64.5) 18 (85.7) 0.016
Medical history, n (%)
Stroke, n (%) 9 (11.8) 6 (8.3) 36 (9.9) 0 (0.0) 0.461
Hypertension 36 (47.4) 45 (62.5) 173 (47.7) 12 (57.1) 0.115
Hyperlipidemia 6 (7.9) 2 (2.8) 48 (13.2) 0 (0.0) 0.012
Diabetes mellitus 4 (5.3) 3 (4.2) 38 (10.5) 4 (19.0) 0.074
Heart disease 3 (3.9) 4 (5.6) 20 (5.5) 2 (9.5) 0.707
Current smoking, n (%) 17 (22.4) 27 (37.5) 67 (18.5) 2 (9.5) 0.003
Size, mm; median (IQR) 5.23 [3.89, 7.96] 4.91 [3.52, 6.91] 5.93 [4.09, 9.79] 9.90 [6.00, 15.30] <0.001
Location, n (%)
Anterior circulation 12 (15.8) 3 (4.2) 55 (15.2) 1 (4.8) 0.033
Posterior circulation 64 (84.2) 69 (95.8) 308 (84.8) 20 (95.2)
Modified fisher grade, n (%)
0-2 59 (77.6) 46 (63.9) NaN NaN NaN
>2 17 (22.4) 26 (36.1) NaN NaN
Laboratory parameter
WBC, 109/L; median (IQR) 6.46 [5.19, 7.65] 10.55 [8.35, 12.61] 5.94 [5.13, 7.07] 8.13 [7.10, 9.31] <0.001
NEUT, 109/L; median (IQR) 3.86 [2.92, 4.70] 8.57 [6.85, 10.93] 3.45 [2.75, 4.23] 6.29 [5.71, 7.44] <0.001
LY, 109/L; mean (SD) 2.06 (0.60) 1.14 (0.47) 2.02 (0.58) 1.15 (0.44) <0.001
NLR, median (IQR) 1.83 [1.47, 2.46] 7.34 [5.80, 10.90] 1.77 [1.37, 2.30] 5.60 [4.52, 6.64] <0.001
CRP, mg/L; median (IQR) 2.53 [1.90, 3.01] 9.10 [6.73, 11.70] 2.44 [1.61, 2.93] 4.27 [3.61, 5.52] <0.001
HDL, mmol/L; mean (SD) 1.23 (0.33) 1.38 (0.36) 1.31 (0.33) 1.34 (0.38) 0.105
LDL, mmol/L; mean (SD) 2.83 [2.15, 3.42] 2.66 [2.29, 3.54] 2.84 [2.20, 3.49] 2.85 [2.06, 3.72] 0.958
TG, mmol/L; median (IQR) 1.48 [0.90, 1.93] 1.20 [0.97, 1.71] 1.29 [1.00, 1.87] 1.21 [0.76, 2.02] 0.597
Apo-A1, g/L; mean (SD) 1.35 (0.29) 1.41 (0.32) 1.48 (0.27) 1.46 (0.28) 0.008
Apo-B, g/L; mean (SD) 0.87 (0.22) 0.92 (0.24) 0.93 (0.24) 0.93 (0.24) 0.404
Body temperature, ° C; mean (SD) 37.6 (7.31) 38.1 (6.95) 36.4 (3.85) 36.7 (3.92) 0.028
Treatment Modality, n (%)
Coiling only 50 (65.8) 61 (84.7) 118 (32.5) 4 (19.0) NA
Stent-assisted coiling or sole stenting 26 (34.2) 10 (13.9) 235 (64.7) 17 (81.0)
Balloon-assisted coiling and others 0 (0.0) 1 (1.4) 10 (2.8) 0 (0.0)

rIAs, ruptured intracranial aneurysms; uIAs, unruptured intracranial aneurysms; NLR, neutrophil-lymphocyte ratio; WBC, white blood cell; NEUT, neutrophil; LY, lymphocyte; CRP, C-reactive protein; HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglyceride; ApoA-1, apolipoprotein A-I; and Apo-B, apolipoprotein B.