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. 2021 Feb 1;13(4):5250–5262. doi: 10.18632/aging.202445

Table 2. Adjusted odds ratio of aneurysm size and prognosis by the NLR and status of aneurysm rupture.

Model 1* Model 2†
Characteristic Groups n Events, n (%) Adjusted OR (95% CI) P Value Adjusted OR (95% CI) P Value
Aneurysm size>10mm NLR<4 with uIAs 363 86 (23.7) Reference Reference
NLR≥4 with uIAs 21 10 (47.6) 2.79 (1.14-6.85) 0.025 2.78 (1.11-6.98) 0.030
NLR<4 with rIAs 76 12 (15.8) Ref Ref
NLR≥4 with rIAs 72 5 (6.9) 0.44 (0.14-1.33) 0.146 0.53 (0.16-1.74) 0.295
Aneurysm Rupture NLR<4 439 76 (17.3) Reference Reference
NLR≥4 93 72 (77.4) 17.07 (9.80-29.72) <0.001 18.46 (10.04-33.92) <0.001
Poor outcome NLR<4 with uIAs 363 4 (1.1) Reference Reference
NLR≥4 with uIAs 21 1 (4.8) 6.39 (0.62-66.01) 0.119 8.58 (0.37-198.94) 0.180
NLR<4 with rIAs 76 7 (9.2) Reference Reference
NLR≥4 with rIAs 72 19 (26.4) 3.16 (1.22-8.21) 0.018 3.29 (1.07-10.15) 0.038
DCI NLR<4 with rIAs 76 11 (14.5) Reference Reference
NLR≥4 with rIAs 72 24 (33.3) 2.85 (1.26-6.45) 0.012 2.75 (1.12-6.73) 0.027

rIAs, ruptured intracranial aneurysms; uIAs, unruptured intracranial aneurysms; NLR, neutrophil-lymphocyte ratio; and DCI, delayed cerebral ischemia; CI, confidence interval; OR, odds ratio.

*Model 1: adjusted for age and sex.

Model 2:

Size: adjusted for model 1+ history of stroke, hypertension, hyperlipidemia, diabetes mellitus, heart disease, smoking status, and aneurysm location.

Aneurysm rupture: adjusted for model 1+ history of stroke, hypertension, hyperlipidemia, diabetes mellitus, heart disease, smoking status, aneurysm location, and aneurysm size.

Poor outcome: adjusted for model 1+ history of stroke, hypertension, hyperlipidemia, diabetes mellitus, heart disease, smoking status, aneurysm location, aneurysm size, treatment modality, and modified Fisher grade.

DCI: adjusted for model 1+ history of stroke, hypertension, hyperlipidemia, diabetes mellitus, heart disease, smoking status, aneurysm location, aneurysm size, treatment modality, and modified Fisher grade.