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. 2021 Feb 11;13(4):6010–6024. doi: 10.18632/aging.202522

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Copyright: © 2021 Lv et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Exosomal LINC00662 contributes to the tumor growth of NSCLC in vivo. (A–D) The effect of exosomal LINC00662 on tumor growth of NSCLC cells in vivo was analyzed by nude mice tumorigenicity assay. The A549 cells were treated with LINC00662 overexpression vector or LINC00662 overexpression exosome. (A) Representative images of dissected tumors from nude mice were presented. (B) The average tumor volume was calculated and shown. (C) The average tumor weight was calculated and shown. (D, E) The protein expression levels of E2F1 and β-actin were examined by Western blot analysis in the tumor tissues. Data are presented as mean ± SD. Statistic significant differences were indicated: * P < 0.05, ** P < 0.01.