FIG 2.

Cell wall-anchored surface proteins. A schematic diagram showing the two CWA proteins apart from the Isd proteins (Fig. 1) that have been analyzed at the molecular level is presented. The preproteins have a signal sequence (S) that promotes secretion across the membrane via the Sec apparatus at the N terminus and a sorting signal (SS) at the C terminus for anchorage to peptidoglycan. The A domain of Fbl is composed of three separately folded subdomains, with N2 and N3 being the minimum required for fibrinogen binding. Region R comprises SDSDSA repeats, which form a flexible stalk. The minimum putative vWF binding domain of Wbl is shown in red.