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. 2013 Sep 13;12(4):469–483. doi: 10.1111/iwj.12142

Figure 5.

Figure 5

Time‐course study of povidone‐iodine (PVP‐I) and cadexomer iodine bactericidal efficacy on PAO1 that was cultured for 0–3 days on porcine explants (without antibiotic pre‐treatment) prior to dressing exposure. (A) Single application of cotton gauze, PVP‐I or 100% cadexomer iodine (Iodoflex™) with bacterial load determined after 1, 12 and 24 hours of exposure. (B) Daily application of PVP‐I with bacterial load determined after 12, 24 and 72 hours of exposure. Single application: 0‐day gauze P‐values were ≤0·001 between all time points and significantly lower at each exposure time compared with the corresponding exposure times of greater biofilm maturity; no significant difference observed between time points within each biofilm maturity level after 1 day with wet gauze. No significant difference observed between time points within each biofilm maturity level of PVP‐I; Iodoflex P‐values were ≤0·001 between time points within each biofilm maturity level after 1 day. No significant difference between corresponding time points at 1 day or greater biofilm maturity with Iodoflex. Daily application of PVP‐I significantly reduced PAO1 (P ≤ 0·05) at 12‐ and 72‐hour exposure compared with wet gauze.