Table 1.

Reported cases of malignant transformation arising in necrobiosis lipoidica

Age/Gender	Diabetes	Duration of NL	Type of cancer	Site	Metastasis	Treatment	Source
57/F	No	32	SCC	Lower limb	Unknown	Unknown	Muller et al., 1966 2
59/F	IDDM	36	SCC	Right outer leg	Inguinal nodes	Below knee amputation and radiotherapy to inguinal region	Clement et al., 1985 3
39/M	No	20	SCC	Bilateral pre‐tibial areas	None	Excision and graft	Kossard et al., 1987 4
69/F	No	40	SCC	Bilateral pre‐tibial areas	Right inguinal nodes	Bilateral amputation	Beljaards et al., 1990 5
46/F	IDDM	11	SCC	Left lower leg	None	Excision and graft	Porneuf et al., 1991 6
44/M	Unknown	12	Leiomyosarcoma	Left pre‐tibial area	None	Excision, graft and postsurgical irradiation	Perrot et al., 1994 7
52/M	NIDDM	6	SCC	Right leg	None	Excision, graft and postsurgical irradiation	Pavithran, 1998 8
46/F	IDDM	29	SCC	Inner left leg	None	Excision and graft	Gudi et al., 2000 9
28/F	IDDM	12	SCC	Left leg	None	Excision and graft	Imtiaz and Khaleeli, 2001 10
76/F	No	30	SCC	Right leg	None	Below knee amputation	Santos‐Juanes et al., 2004 1
33/M	IDDM	18	SCC	Right leg	Disseminated	Radiotherapy	Vanhooteghem et al., 2005 11
40/F	IDDM	12	SCC	Left medial lower leg	None	Excision and graft	McIntosh et al., 2005 12
53/F	IDDM	25	SCC	Right medial leg	None	Excision and graft	Lim et al., 2006 13
68/M	NIDDM	18	SCC	Left distal forearm	Left axilar nodes	Above elbow amputation	Present case, 2013

F, female; M, male; IDDM, insulin‐dependent diabetes mellitus; NDDM, non‐insulin‐dependent diabetes mellitus; NL, necrobiosis lipoidica; SCC, squamous cell carcinoma.