Figure 1.

(A) Top: chemistry for novel nitric oxide gas (gNO)‐producing probiotic patch in which gNO is generated from nitrite and protons produced by Lactobacillus fermentum NCIMB 7230 bacteria from glucose. (B) Bottom: cross section of novel gNO‐producing probiotic patch design. From the outermost to innermost layers, the patch is composed of (a) adhesive non occlusive Tegaderm™, (b) polyethylene/nylon laminated film, (c) immobilised bacteria L. fermentum NCIMB 7230 and a solution containing 10% glucose, 30 mM NaNO₂ and 0·85% NaCl and (d) a layer of adhesive non occlusive Tegaderm™.