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. 2012 Jun 4;10(4):441–454. doi: 10.1111/j.1742-481X.2012.01003.x

Figure 3.

Figure 3

Photomicrograph of sulphur mustard (SM) (10 mg/kg) treated mouse skin sections taken at various time intervals, haematoxylin and eosin (H&E). Bar = 25 µm. (A) 0 hours (control) showing normal arrangement of epidermis, dermis and adnexa. (B) 3 hours showing hyperplasia of epidermal cells, pyknotic nuclei of basal cells (arrow) and oedema of dermis along with mild inflammatory reaction. (C) 6 hours showing coagulative necrosis of epidermis follicular degeneration (arrow), dermoepidermal separation (arrow head) and excessive infiltration of inflammatory cells. (D) 24 hours showing hyperkeratinisation (arrow), necrosis of epidermis, dermoepidermal separation (arrow head) along with transmigrated monocytoid cells and neutrophils. (E) 72 hours showing coagulative necrosis of epidermis extending deep into the dermis, follicular degeneration (arrow) that were roofed by necrosed inflammatory cells entrapped in fibrinous exudates (arrow head). (F) 168 hours showing coagulative necrosis of epidermis and dermis, atrophied adnexa (arrow head) and necrosed inflammatory cells in dermis roofed by eschar tissue (arrow).