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. 2012 Jun 4;10(4):441–454. doi: 10.1111/j.1742-481X.2012.01003.x

Figure 6.

Figure 6

Immunohistological localization of transforming growth factor alpha (TGF‐α) in sulphur mustard (SM) (5 or 10 mg/kg, diluted in acetone) treated mouse skin sections taken at various time intervals. Bar = 25 µm. (A) 0 hours showing marked expression of TGF‐α (arrow) in epidermal cells and hair follicles of mouse skin after SM (5 mg/kg) exposure. (B) 24 hours after SM (5 mg/kg) treatment showing increased immunoreactivity of TGF‐α in dermis by fibroblast cells (arrow) and macrophages (arrowhead) and reduced immunoreactivity in epidermal cells and hair follicles compared to (A). (C) 24 hours (SM 10 mg/kg) showing similar immunoreactivity of TGF‐α in dermis by fibroblast and infiltrating macrophages as shown by mice skin after SM (5 mg/kg) exposure in (B). (D) 168 hours (SM 10 mg/kg) showing marked increase in immunosignals of TGF‐α diffused throughout the dermis compared to (B) and (C).