Table 2.
Summary incidence table of mice skin lesions at various time intervals after single percutaneous exposure to sulphur mustard (SM) (5 or 10 mg/ kg)
| Lesions | Dose of SM | Time in hours | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 3 | 6 | 12 | 24 | 48 | 72 | 168 | ||
| Epidermal necrosis | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(4) | 6/6(4) | 6/6(4) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(4) | 6/6(4) | 6/6(4) | |
| Vacuolation of basal cells | 5 mg/kg | 0/6(0) | 1/6(1) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(4) | 6/6(4) | 4/6(2) | 4/6(2) |
| 10 mg/kg | 0/6(0) | 3/6(1) | 6/6(2) | 6/6(2) | 6/6(3) | 6/6(4) | 6/6(4) | 4/6(2) | 4/6(2) | |
| Necrosis of basal cells | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(1) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(3) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(4) | 6/6(4) | |
| Hyperplasia/ hypertrophy of basal cells | 5 mg/kg | 0/6(0) | 2/6(2) | 4/6(2) | 4/6(3) | 4/6(3) | 5/6(3) | 5/6(3) | 5/6(3) | 6/6(3) |
| 10 mg/kg | 0/6(0) | 3/6(2) | 4/6(2) | 4/6(3) | 4/6(3) | 4/6(3) | 4/6(3) | 5/6(3) | 4/6(3) | |
| Dermoepidermal separation | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(2) | 4/6(2) | 4/6(2) | 6/6(2) | 6/6(3) | 6/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 2/6(1) | 4/6(2) | 6/6(2) | 6/6(2) | 6/6(3) | 6/6(2) | 6/6(2) | |
| Re‐epithelialisation | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(2) | |
| Oedema | 5 mg/kg | 0/6(0) | 3/6(2) | 5/6(3) | 5/6(3) | 5/6(2) | 4/6(1) | 4/6(2) | 2/6(1) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 5/6(2) | 5/6(4) | 5/6(4) | 5/6(3) | 4/6(1) | 4/6(2) | 3/6(1) | 5/6(2) | |
| Transmigration of inflammatory cells | 5 mg/kg | 0/6(0) | 4/6(2) | 5/6(3) | 5/6(4) | 5/6(4) | 5/6(4) | 5/6(3) | 5/6(3) | 4/6(2) |
| 10 mg/kg | 0/6(0) | 5/6(2) | 5/6(3) | 5/6(4) | 5/6(4) | 5/6(4) | 5/6(3) | 4/6(2) | 4/6(2) | |
| Proliferation of fibroblast | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(2) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(2) | 3/6(2) | |
| Collagen synthesis | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 4/6(1) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(1) | 3/6(2) | |
| Adnexal atrophy | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 3/6(1) | 3/6(2) | 5/6(3) | 5/6(3) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 1/6(1) | 4/6(2) | 4/6(3) | 5/6(3) | 5/6(4) | 5/6(3) | |
| Hypertrophy/ hyperplasia of adnexal wall | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(2) | 4/6(2) | 5/6(3) | 5/6(3) | 4/6(3) | 5/6(3) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 2/6(2) | 5/6(2) | 3/6(3) | 3/6(3) | 4/6(3) | 4/6(3) | |
| Vascular proliferation (neovascularization) | 5 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 3/6(1) | 5/6(2) |
| 10 mg/kg | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 0/6(0) | 3/6(1) | 5/6(2) | |
Values in cell represents number of animals showing lesions/total number of animals (severity).