Table 2.
The role of Smurfs in various cancer types.
| Smurfs | Cancer type | Downstream protein | Promotion of biological processes | Inhibition of biological processes | Reference |
|---|---|---|---|---|---|
| Smurf1 | lung cancer | PIPKIγ | / | growth, tumorigenesis | (38) |
| colorectal cancer | DAB2IP | proliferation, survival, migration | / | (16) | |
| colorectal cancer | ER effectors | / | apoptosis | (41) | |
| colorectal cancer | RhoB | / | apoptosis | (20) | |
| colorectal cancer | RhoA | migration | / | (52) | |
| colon cancer | p53 | growth, migration | / | (44) | |
| breast cancer | RhoA | migration | / | (70) | |
| Smurf2 | bladder cancer | TβR | / | EMT, invasion | (42) |
| hepatoma | Smad3 | / | migration, invasion | (49) | |
| breast cancer | TβRI | / | EMT, invasion, migration | (18) |