Fig. 2.

Effect of hypertonic NaCl on the healing corpus I_sc. Experimental ulcers were induced to one side of the gastric corpus in wild-type mice by acetic acid (Methods). 30 days or 8 months later, muscle-stripped tissue was mounted in the Ussing chamber from the regenerated healed ulcer region (Regen, red) and the non-ulcerated contralateral region (Intact, black). Tissues were exposed to 0.5 M NaCl challenge as in Fig. 1. a Representative time course of I_sc for tissue 30 days after ulceration. b Baseline I_sc of 30-day tissue after ulcer induction. c Percent (%) I_sc recovery (Methods) of 30-day mucosa 2 h after 0.5 M NaCl. d Baseline I_sc of tissue 8 months after ulceration. e Percent (%) I_sc recovery of 8-mo mucosa 2 h after hypertonic NaCl. Mean ± SEM (n = 4 30-day or 8 months) for each tissue condition **P < 0.01 Intact versus Regen (two-tailed t test)